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Author: Admin | 2025-04-28
Sexual performance enhancing products. Curr Neuropharmacol 2017; 15: 724-730. [CrossRef]36. Pichi ni S, Marchei E, Paci ci R, Marinelli E, Busardò FP. Chemsex intoxication involving sildenal as an adulterant of GHB. Drug Test Anal 2017; 9: 956-959. [CrossRef]37. Giorgetti R, Tagliabracci A, Schif ano F, Zaami S, Marinelli E, Bu-sardò FP. When “chems” meet sex: a rising phenomenon called “ChemSex”. Curr Neuropharmacol 2016; 15: 762-770.116Şimşek et al.The eect of sildenal in rats with jaundice ... Liver function tests did not show statistical significant changes between the 10th and 28th day in sildenafil-treated rats (p>0.05) [16]. ...... This was done using the modified Jaffe's method [16]. ...... The sildenafil-treated groups at different time points didn't show any statistical difference in histopathological changes (p>0.05) [16]. ...This study investigated the various effects of Sildenafil citrate on the liver, kidney and heart of male albino rats. Twenty eight male rats randomly divided into 4 groups and weighing 131-214g were used. While the animals in group 1 (control) received food and water only, those in the study groups 2,3&4 respectively received 25mg/kg, 50mg/kg and 100mg/kg of Sildenafil citrate orally, daily for 4 weeks. All animals were sacrificed and blood samples collected by cardiac puncture for analysis of biochemical parameters. The rats Liver, kidneys and hearts were subjected to histopathological tests. Study results showed no changes in food consumption, fluid intake, body weight and relative organ weight of the animals. The animals in group 4 showed significant increase in mean Lactate dehydrogenase and Aspartate aminotransferase ⃰(P... The results are in agreement with the works of Ibama et al. [30], in which the administration of sildenafil and revive capsules were seen not to be hepatotoxic. Sildenafil citrate has been reported to reverse biochemical/histopathological changes in the liver due to jaundice and offer hepatoprotective action against drug-induced hepatotoxicity [31,32]. Some other studies have however reported hepatotoxic effects of increasing doses of sildenafil and the combination of sildenafil and tramadol in experimental models [1,33]. ...Erectile dysfunction, premature ejaculation and pleasure seeking have increased the use of sildenafil citrate, tramadol and their combination by youths who believe these drugs could positively impact their sexual life. Sildenafil citrate and tramadol are metabolized in the liver, and their by-products excreted through the kidneys, making these organs possible targets for toxicity. Aim: This study evaluates the effects of combination of tramadol and sildenafil citrate on hepatic and renal function parameters in male albino rats. Methodology: A total of forty-nine (49) male albino rats weighing between 150 to 180g were used for the study. Sildenafil citrate and tramadol were administered to the rats by means of oral gavage for 28 days. The liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined using the Reitman-Frankel method. Alkaline phosphatase (ALP) was determined using the Colorimetric endpoint method. Total protein (TP) was determined using the biuret method. Albumin (ALB) was determined using the bromocresol green method. Sodium (Na+), potassium (K+) and chloride (CL-) were determined using ion selective electrode (ISE) method. Bicarbonate (HCO3-) was determined
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