Comment
Author: Admin | 2025-04-28
And emergency treatment with a contraindicated drug (e.g., linezolid, intravenous methylene blue, direct-acting sympathomimetic drugs such as epinephrine) becomes necessary and cannot be delayed, discontinue tranylcypromine tablets as soon as possible before initiating treatment with the other agent, and monitor closely for adverse reactions. Table 3: Clinically Significant Drug Interactions with Drug Classes * ProductClinical Comment on Concomitant Use †Predominant Effect/Risk [Hypertensive Reaction (HR) ‡ or Serotonin Syndrome (SS) §] * Some drugs in these groups may also be listed in Table 4 below. † [See Contraindications (4.1)] ; ‡ [See Warnings and Precautions (5.2)] ; § [See Warnings and Precautions (5.3)] ¶ If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals, use agent at the lowest appropriate dosage, monitor for effects of the interaction, advise the patient to report potential effects). # [See Warnings and Precautions (5.5)] ; Þ [See Warnings and Precautions (5.14)] ; ß [See Overdosage (10.1)] à Sympathomimetic drugs include amphetamines as well as cold, hay fever or weight-reducing products that contain vasoconstrictors such as pseudoephedrine, phenylephrine, and ephedrine) Agents with blood pressure-reducing effects Use with caution ¶ Hypotension # Non-selective H1 receptor antagonists Contraindicated † Increased anticholinergic effects Beta-adrenergic blockers (see also agents or procedures with blood pressure-reducing effects) Use with caution ¶ More pronounced bradycardia, postural hypotension # Blood glucose-lowering agents Dosage reduction of such agents may be necessary. Monitor blood glucose. Excessive reduction of blood glucose (additive effect) Þ CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution ¶ Increased CNS depression Dietary supplements containing sympathomimetics Contraindicated † Antidepressants including but not limited to: • Other MAOIs (e.g., linezolid, intravenous methylene blue, selective MAOIs) • Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) • Tricyclic antidepressants • Amoxapine, bupropion, maprotiline, nefazodone, trazodone, vilazodone, vortioxetine Contraindicated † SS for all antidepressants For MAOIs, increased MAO inhibition and risk of adverse reactions, SS, and HR ß Amphetamines and methylphenidates and derivatives Contraindicated † HR Sympathomimetic drugs à Contraindicated † HR; Including risk of intracerebral hemorrhage Triptans Contraindicated † SS Table 4: Clinically Significant Drug Interactions with Individual Products * ProductClinical Comment on Concomitant Use †Predominant Effect/Risk [Hypertensive Reaction (HR) ‡ or Serotonin Syndrome (SS) §] * Some drugs in this table may also belong to groups listed in Table 3 above, and may be associated with additional interactions. † [See Contraindications
Add Comment