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Author: Admin | 2025-04-28
They are not meant to be used long term. There are several different PPIs available to treat GERD. The formulations that are available without a prescription include: Nexium 24H (esomeprazole)Prilosec OTC (omeprazole)Prevacid 24H (lansoprazole)Zegerid OTC (omeprazole/sodium bicarbonate) Some of the PPI brands that are available over the counter are also available in prescription forms. However, Aciphex (rabeprazole), Dexilant (dexlansoprazole), and Protonix (pantoprazole) are only available as a prescription:Aciphex (rabeprazole)Dexilant (dexlansoprazole)Nexium (esomeprazole)Prilosec (omeprazole)Prevacid (lansoprazole)Protonix (pantoprazole) Histamine Blockers Histamine blockers (H2 blockers or H2-receptor antagonists) are another class of medications used to treat GERD. H2 blockers, similar to PPIs, block signals from certain cells in the stomach that promote the production of stomach acid. This process reduces acid overall and may help reduce the symptoms of GERD. H2 blockers may not be the first choice for treating GERD, but they might be used as a "step-down" therapy to treat certain aspects of GERD. There are currently two H2 blockers approved for treating GERD. Two others, Zantac (ranitidine) and nizatidine, have been recalled by their manufacturers based on an advisory from the Food and Drug Administration (FDA) and are no longer on the market. The H2 blockers that are currently available in both OTC and prescription strength are: Pepcid (famotidine)Tagamet (cimetidine)Zantac 360 (famotidine)Zantac RecallZantac (ranitidine) was removed from the market in April 2020 due to unacceptable levels of a substance called N-Nitrosodimethylamine (NDMA) in the drug. NDMA is thought to cause cancer in humans. A new formulation containing the H2 blocker famotidine is available under the brand name Zantac 360.Laboratory testing found NDMA in samples of Zantac. It also revealed that the levels of NDMA increased with time and temperature, meaning that the older the product, the higher the level of NDMA it might contain. Prokinetic Agents Prokinetic agents are not commonly used
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