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Author: Admin | 2025-04-28
Of CNS infections, including meningitis and brain abscessEndocarditis: Treatment of endocarditisGynecologic infections: Treatment of gynecologic infections including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection (also caused by Clostridium spp., Peptococcus spp., Peptostreptococcus spp., and Fusobacterium spp.)Intra-abdominal infections: Treatment of intra-abdominal infections, including peritonitis, intra-abdominal abscess, and liver abscess (also caused by Clostridium spp., Eubacterium spp., Peptococcus spp., and Peptostreptococcus spp.)Lower respiratory tract infections: Treatment of lower respiratory tract infections, including pneumonia, empyema, and lung abscessSkin and skin structure infections: Treatment of skin and skin structure infections (also caused by Clostridium spp., Peptococcus spp., Peptostreptococcus spp., and Fusobacterium spp.)Surgical prophylaxis (colorectal surgery): Injection: Preoperative, intraoperative, and postoperative prophylaxis to reduce the incidence of postoperative infection in patients undergoing elective colorectal surgery classified as contaminated or potentially contaminatedTrichomoniasis: Treatment of infections caused by Trichomonas vaginalis, including treatment of asymptomatic sexual partners Use: Off LabelBalantidiasiscyesData from a single case report of one immunocompromised patient with pulmonary infection treated with metronidazole suggest that metronidazole may be beneficial for the treatment of balantidiasis Anagyrou 2003. Clinical experience also suggests the utility of metronidazole in the treatment of balantidiasis CDC 2013.Bite wound infection, prophylaxis or treatment (animal or human bite)yesBased on the Infectious Diseases Society of America (IDSA) guidelines for the diagnosis and management of skin and soft tissue infections (SSTIs), metronidazole, in combination with other appropriate agents, is an effective and recommended alternative for treatment of bite wounds.Clostridioides (formerly Clostridium) difficile infectionyesBased on the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) guidelines for Clostridioides (formerly Clostridium) difficile infection, oral metronidazole is an effective and recommended alternative agent for the management of initial episodes of nonsevere (WBC ≤15,000 cells/mm3 and serum creatinine C. difficile infections if access to vancomycin or fidaxomicin is limited or use is contraindicated. IV metronidazole is recommended in combination with oral and/or rectal vancomycin for fulminant C. difficile infections, particularly when ileus is present. Metronidazole should not be used for prolonged therapy because of the potential for cumulative and potentially irreversible neurotoxicity; oral metronidazole should not be used for recurrent infections.Crohn disease, management
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