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Author: Admin | 2025-04-28
Problems with impulse control or compulsive behaviors.According to the drugs’ package inserts, “case reports suggest that patients can experience intense urges to gamble, increased sexual urges, intense urges to spend money, binge or compulsive eating, and/or other intense urges, and the inability to control these urges.”3Carbidopa-levodopa (Sinemet) shares this same warning. More recently, the antipsychotic aripiprazole (Abilify) has been linked with compulsive behavior side effects such as compulsive gambling in some patients.6. Stevens-Johnson SyndromeStevens-Johnson syndrome (SJS) is a rare, life-threatening hypersensitivity reaction of the skin and mucous membranes. During SJS, large macules rapidly spread and form together, leading to blistering, necrosis, and shedding of the skin.5Lamotrigine (Lamictal) has a relatively high incidence of SJS, especially when initiated at high doses, which led the FDA to require a black box warning on its package labeling to inform consumers of this risk. Other medications that may cause SJS include allopurinol (Zyloprim), acetaminophen (Tylenol), ibuprofen (Motrin), naproxen (Aleve), sulfa drugs, penicillin, barbiturates, and other anticonvulsants.67. Birth DefectsA birth defect occurs while a baby develops in the mother’s body. An estimated 1 in every 33 babies in the United States is born with a birth defect.7Thalidomide is one of the oldest and well-known teratogenic medications. In 1954, thousands of women took the medication—which was then promoted as a wonder drug for treating insomnia, coughs, colds, and headaches—resulting in the death of approximately 2000 children and serious birth defects in more than 10,000 children.Known teratogenic prescription medications include warfarin, divalproex (Depakote), Paxil, topiramate (Topamax), methotrexate (Rheumatrex), angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, nonsteroidal anti-inflammatory drugs, oral contraceptives, statins, and tetracyclines.Although the risk for birth defects is highest during the first trimester, women should consult their health care providers about the risk and benefits of all medication use during any stage of pregnancy.8. Cancer One of the most surprising instances of a medication related to cancer came when tamoxifen (Nolvadex), which is used to treat breast cancer, was found to increase the risk of uterine cancer. In response, the FDA required the manufacturer to add a black box warning to inform consumers of the risk.The labeling of type 2 diabetes medication pioglitazone (Actos) includes a warning about an increased risk of bladder cancer, which stemmed from data from an observational study.All glucagon-like peptide-1 receptor agonists have a black box warning concerning the risk for thyroid C-cell tumors that has been seen in rats and mice. Animal studies have also shown metronidazole (Flagyl) to be carcinogenic.9. SuicidalityThis issue stems back to reports in 1990 that Paxil could lead to suicidality in patients.8 Today, all antidepressants have a black box warning in their labeling about the increased risk of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder and other psychiatric disorders.Current clinical evidence on the topic is inconclusive. Some studies have shown that the use of antidepressants correlates with increased risk of suicidal actions, while other studies have not demonstrated any increased risk.Other medications that may be associated with suicidal thinking
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