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Author: Admin | 2025-04-28
Target dose of 600 mg in the morning and 1.2 g at bedtime (Pinkerton 2014)Discontinuation of therapy: In patients receiving gabapentin chronically, unless safety concerns require a more rapid withdrawal, gabapentin should be withdrawn gradually over ≥1 week to minimize the potential of increased seizure frequency (in patients with epilepsy) or other withdrawal symptoms (eg, confusion, irritability, tachycardia, diaphoresis) (Norton 2001; Tran 2005).Dosing: GeriatricRestless legs syndrome (off-label use): Immediate release: Oral: Initial: 100 mg once daily (IRLSSG/EURLSSG/RLS-F [Garcia-Borreguero 2016])Other indications: Refer to adult dosing. For postoperative pain (off-label use), some experts avoid use in patients >65 years of age (Joshi 2018).Discontinuation of therapy: Refer to adult dosing.Dosing: PediatricNote: Do not exceed 12 hours between doses with 3 times daily dosing. Pediatric doses presented as mg/kg/day and mg/kg/dose; use precaution.Seizures, partial onset; adjunctive therapy: Oral: Immediate release: Note: If gabapentin is discontinued or if another anticonvulsant is added to therapy, it should be done slowly over a minimum of 1 week.Children 3 to Initial: 10 to 15 mg/kg/day divided into 3 doses daily; titrate dose upward over ~3 daysMaintenance usual dose:Children 3 to 4 years: 40 mg/kg/day divided into 3 doses daily; maximum daily dose: In one long-term study, doses up to 50 mg/kg/day were well-toleratedChildren 5 to day divided into 3 doses daily; maximum daily dose: In one long-term study, doses up to 50 mg/kg/day were well-toleratedChildren ≥12 years and Adolescents: Initial: 300 mg 3 times daily; titrate dose upward if needed; usual maintenance dose: 900 to 1,800 mg/day divided
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