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Author: Admin | 2025-04-28
Mg/day150 mg/daily165 mg/day225 mg/daily247.5 mg/day*300 mg/daily330 mg/day450 mg/daily495 mg/day†600 mg/daily660 mg/day‡ Patients with Renal ImpairmentUse of LYRICA CR is not recommended for patients with creatinine clearance (CLcr) less than 30 mL/min or who are undergoing hemodialysis. Those patients should receive LYRICA.In view of dose-dependent adverse reactions and because pregabalin is eliminated primarily by renal excretion, adjust the dose in patients with reduced renal function. Base the dose adjustment in patients with renal impairment on CLcr, as indicated in Table 2. To use the dosing tables, an estimate of the patient’s CLcr in mL/min is needed. CLcr in mL/min may be estimated from serum creatinine (mg/dL) determination using the Cockcroft and Gault equation:Next, refer to the Dosage and Administration section to determine the recommended total daily dose based on indication, for a patient with normal renal function (CLcr greater than or equal to 60 mL/min). Then refer to Table 2 to determine the corresponding renal adjusted dose.(For example: A patient initiating LYRICA CR therapy for postherpetic neuralgia with normal renal function [CLcr greater than or equal to 60 mL/min], receives a single daily dose of 165 mg/day pregabalin. Therefore, a renal impaired patient with a CLcr of 50 mL/min would receive a single daily dose of 82.5 mg.)Table 2. LYRICA CR Dosage Adjustment Based on Renal Function*495 mg = 3 × 165 mg tablets taken once a day.†660 mg = 2 × 330 mg tablets taken once a day.‡247.5 mg = 3 × 82.5 mg tablets taken once a day.Creatinine Clearance (CLcr)(mL/min)Total LYRICA CR Daily Dose(mg/day)Dose Regimengreater than or equal to 60165330495*660†Once a day30-6082.5165247.5‡330Once a dayless than 30/hemodialysisDose with LYRICAFrequently asked questionsIs Lyrica a controlled substance / narcotic?Does Lyrica make you sleepy?Lyrica vs Gabapentin: What's the difference?How long does it take for Lyrica to work?How long does Lyrica stay in your system?Can you stop Lyrica cold turkey?Further informationAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Medical Disclaimer
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