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Author: Admin | 2025-04-28
Lithium on body weight of obese and non-obese patients with type-1 bipolar disorder. Researchers conducted a post-hoc analysis of data from multiple 18-month double-blind, placebo-controlled trials consisting of 155 obese and 399 non-obese patients. The patients received either: lamotrigine, lithium, or a placebo for the 18-month duration.Results noted that individuals with obesity exhibited: weight loss of 9.25 lbs. (4.2 kg) with lamotrigine treatment; weight gain of 13.44 lbs. (6.1 kg) with lithium treatment; and weight loss of 1.32 lbs. (0.6 kg) with placebo. Non-obese patients exhibited: weight loss of 1.1 lbs. (0.5 kg) with lamotrigine; weight gain of 2.42 lbs. (1.1 kg) with lithium; and weight gain of 1.54 lbs. (0.7 kg) with placebo. This study supports the idea that lamotrigine treatment facilitates weight loss – particularly among those with obesity.Source: https://www.ncbi.nlm.nih.gov/pubmed/168162242006: Effects of lamotrigine and lithium on body weight during maintenance treatment of bipolar I disorder.Sachs, Bowden, Calabrese, et al. retrospectively analyzed the impact of lamotrigine treatment on body weight of persons with bipolar disorder. Data for the retrospective analysis was derived from multiple double-blind, placebo-controlled, 18-month trials testing lamotrigine and lithium for the management of bipolar disorder. In the trials, a total of 227 patients received lamotrigine, 166 received lithium, and 190 received a placebo.Results indicated that lamotrigine recipients exhibited no significant change in body weight; weight remained stable throughout the 18 months. An analysis by researchers determined that, on average, lamotrigine users exhibited an average weight loss of 2.64 lbs. (1.2 kg) over a 52-week span. It was further stated that 12.1% of lamotrigine recipients exhibited clinically significant weight loss as a result of treatment. Researchers concluded that lamotrigine’s effect on body weight is analogous to that of a placebo.Source: https://www.ncbi.nlm.nih.gov/pubmed/165421882005: Drug-induced weight gain.Ness-Abramof and Apovian published a paper discussing drug-induced weight gain. In the paper, the authors state that weight gain is a problematic side effect of many pharmaceutical medications in that increased body weight often compromises health of the user – and frequently interferes with treatment compliance. Authors briefly discuss the fact that many neuropsychiatric medications, including: antipsychotics, antidepressants, and mood stabilizers –induce weight gain. That said, it was further mentioned that lamotrigine appears to be weight neutral.Source: https://www.ncbi.nlm.nih.gov/pubmed/162348782004: Safety and tolerability of lamotrigine for bipolar disorder.Bowden, Asnis, Ginsberg, et al. reviewed data from 8 placebo-controlled clinical trials (comprised of 1800 participants) and 4 unpublished studies in which lamotrigine was administered to treat bipolar disorder.
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