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Author: Admin | 2025-04-28
Spray. Repeat priming process (using only 2 sprays rather than 4) if inhaler is not used for >7 days.Before first use, ensure that pointer on dose indicator is pointing to the right of the 120 or 30 inhalation mark in the dose indicator display window for the 120- or 28-inhalation canister, respectively. Color in the display window will change to red when there are only 20 or 10 sprays remaining in the inhaler for the 120- or 28-inhalation canister, respectively.To administer a dose, remove cap from mouthpiece. Shake inhaler well before each use. Hold inhaler with mouthpiece pointing toward face; exhale through mouth as fully and as comfortably as possible. Close lips around mouthpiece and tilt head back, keeping tongue below mouthpiece. While inhaling slowly and deeply, press down on center of dose indicator until canister stops moving in actuator and spray is released, then stop pressing. After inhaling, remove mouthpiece and hold breath as long as comfortably possible, up to 10 seconds, then breathe out gently. Repeat process for second inhalation. Replace cap on mouthpiece immediately after use.Clean inhaler once weekly to avoid drug buildup, which can block spray through the mouthpiece. To clean inhaler, first remove canister from actuator; do not clean canister or allow it to get wet. Remove cap from mouthpiece. Rinse actuator under warm water for about 30 seconds. Turn actuator upside down; rinse actuator again through mouthpiece for about 30 seconds. Shake as much water off mouthpiece as possible. Check the actuator and mouthpiece; if any drug buildup remains, repeat rinsing procedure. Allow the actuator to dry overnight. Do not put canister back into the actuator while wet. When the actuator is dry, gently press canister down into it; do not press too hard on canister since this may cause drug release. Prime inhaler after each cleaning by shaking well and releasing 2 sprays into the air away from face.After priming of the oral aerosol inhaler containing glycopyrrolate/formoterol (Bevespi Aerosphere), each actuation of the inhaler delivers 10.4 mcg of glycopyrrolate (equivalent to 8.3 mcg of glycopyrronium) and 5.5 mcg of formoterol fumarate from the valve. Dosage is expressed in terms of drug delivered from the actuator; each actuation of the inhaler delivers 9 mcg of glycopyrrolate (equivalent to 7.2 mcg of glycopyrronium) and 4.8 mcg of formoterol fumarate from the mouthpiece. Actual amount of drug delivered to the lungs depends on factors such as patient's coordination between actuation of the device and inspiration through the delivery system. The Bevespi Aerosphere inhalation aerosol delivers 28 or 120 metered sprays per 5.9- or 10.7-g canister, respectively.DosagePediatric PatientsDroolingOral (Solution)Children and adolescents 3–16 years of age: Initial dosage of 0.02 mg/kg 3 times daily; may titrate in increments
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