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Author: Admin | 2025-04-28
World setting differ from those obtained under the strict controls of a clinical trial. Results from two small reviews of patients treated in the real world setting - outside of a clinical trial - indicate that patients with psoriasis may experience symptom improvement starting as early as 4 weeks after treatment is started.A chart review performed on 38 patients who attended a dermatology clinic in Canada and who were treated with Taltz to manage their psoriasis, was one of the small reviews that reported some patients showed signs of improvement 4 weeks after starting treatment . Patients were followed for an average of 32 weeks, during which time 70% of patients achieved PASI 100.In a separate small review of 15 psoriasis patients treated with Taltz in a real-world setting, all patients showed improvement in their symptoms after 4 weeks’ treatment. After 12 weeks, all of the patients reached PASI 50, 80% reached PASI 75, 13% reached PASI 90 and 6.9% reached PASI 100. Both groups of researchers cautioned that further research was needed to confirm their results, however. ReferencesPapp KA, Leonardi CL, Blauvelt A, et al. Ixekizumab treatment for psoriasis: integrated efficacy analysis of three double-blinded, controlled studies (UNCOVER-1, UNCOVER-2, UNCOVER-3). Br J Dermatol. 2018 Mar;178(3):674-681. doi: 10.1111/bjd.16050.Gulliver W, Penney M, Power R, et al. Moderate-to-severe plaque psoriasis patients treated with ixekizumab: early real-world outcomes and adverse events. J Dermatolog Treat. 2020 Apr 22:1-7. doi: 10.1080/09546634.2020.1755009.Diotallevi F, Campanati A, Radi G, et al. Ixekizumab for treatment of moderate to severe plaque psoriasis: real world clinical experience. G Ital Dermatol Venereol. 2018 Nov 9. doi: 10.23736/S0392-0488.18.06094-7.Blauvelt A, Leonardi C, Elewski B, et al. A head-to-head comparison of ixekizumab vs. guselkumab in patients with moderate-to-severe plaque psoriasis: 24-week efficacy and safety results from a randomized, double-blinded trial [published online ahead of print, 2020 Sep 2]. Br J Dermatol. 2020;10.1111/bjd.19509. doi:10.1111/bjd.19509. Read next What are monoclonal antibodies? Monoclonal antibodies (mAbs) are man-made proteins that mimic the natural antibodies produced by our immune systems. Monoclonal antibodies can be formulated into medicines to treat various types of illnesses, such as cancer, rheumatoid arthritis or psoriasis. Continue reading How does Taltz compare to Cosentyx for psoriatic arthritis? Taltz and Cosentyx are similar in the way they work, their side effects, and their potential for interactions, but Taltz does appear to provide patients with psoriatic arthritis (PA) with more quality-adjusted life-years (QALYs) compared with Cosentyx at a
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