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Author: Admin | 2025-04-28
Such as amitriptyline.May not be suitable for some people including those who are in the acute recovery phase following a myocardial infarction, undiagnosed bipolar disorder, a history of seizures, urinary retention, or angle-closure glaucoma. Do not use high dosages of amitriptyline in people with cardiovascular disease. Close supervision is recommended when giving to people with thyroid disease.May cause mild pupil dilation, which may trigger an episode of angle-closure glaucoma.May interact with several other drugs including those that are metabolized by hepatic enzymes CYP2D6 or other drugs that cause sedation or with anticholinergic side effects (such as dry mouth, urinary retention, blurred vision, constipation). Extremely high fever (hyperpyrexia) has been reported when amitriptyline has been administered with antipsychotics or anticholinergic drugs.Not approved for use in children.Do not use during pregnancy unless the benefits outweigh the risks. Amitriptyline has been shown to cross the placenta and there have been a few reports of adverse events, although a causal relationship has not been established. Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects 4. Bottom Line Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as chronic pain, fibromyalgia, or insomnia. 5. Tips Take exactly as your doctor has prescribed. If amitriptyline makes you sleepy, talk to your doctor about taking higher dosages later in the afternoon or in the evening to minimize daytime sedation. Read the medication guide supplied by your pharmacy that tells you about amitriptyline. If you have any further questions, talk with your doctor or pharmacist.Do not stop suddenly as withdrawal symptoms may occur. Reducing the dosage slowly over weeks to months is recommended. Tell your doctor if your depression worsens or if you develop suicidal thoughts, particularly during the first few months of therapy. Also, monitor for serotonin syndrome. Report any unusual side effects to a doctor. May increase the risk of sunburn; protect yourself from the sun when outdoors.Do not take other medications with amitriptyline until first checking with your doctor or pharmacist that these are compatible.Tell your doctor if you are pregnant or intending to become pregnant, or breastfeeding. 6. Response
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