5 So, although niacin increases HDL-C, it has minimal to no effect on increasing HDL-P. Niacin is an LDL-lowering drug, specifically lowering LDL particle
There are several basic mechanisms by which a drug can raise HDL cholesterol: an increase in the uptake of cholesterol from tissues by HDLs; an increase in the transfer of cholesterol from other lipoproteins to HDLs; a reduction of the rate of transfer of cholesteryl esters from HDLs to the liver; and a reduction of cholesteryl ester transfer
While higher HDL levels are correlated with lower risk of cardiovascular diseases, no medication used to increase HDL has been proven to improve health. [2] [32] As of 2024, numerous lifestyle changes and drugs to increase HDL levels were under study. [2]
by RS Rosenson Cited by 42As examples, simvastatin and rosuvastatin appear to raise HDL cholesterol more as the dose is increased, while the increase in HDL cholesterol
HDL cholesterol can be a bad thing, drug companies remain invested in identifying drugs to increase HDL cholesterol. Merck recently
The findings raise questions about drugs in development to raise HDL to prevent heart attacks, he said. Raising HDL through increased ApoA-1
There are several basic mechanisms by which a drug can raise HDL cholesterol: an increase in the uptake of cholesterol from tissues by HDLs; an increase in the transfer of cholesterol from other lipoproteins to HDLs; a reduction of the rate of transfer of cholesteryl esters from HDLs to the liver; and a reduction of cholesteryl ester transfer
However, low levels of HDL cholesterol have not been established as causative of this increase in risk. (See 'Low HDL cholesterol as an ASCVD risk factor' below and 'Effect of increasing HDL cholesterol on clinical outcome' below.) This topic will address clinical aspects of abnormal HDL (the particle) and HDL cholesterol.
Rosuvastatin is an oral drug for lowering blood cholesterol levels. Rosuvastatin is used for the reduction of blood total cholesterol, HDL cholesterol, and triglyceride levels, and to increase HDL cholesterol levels.
Isaac Asimov’s Three Laws of Robots does not apply here. Lots of possibilities.
Howard Campbell could be named after John W. Campbell who shaped sci-fi for the readers’ enjoyment.
Shame on HDL for not providing a sequel for his readers. Not nice to leave them hanging.
The story has a single focus. Expand the scope with subplots which become plots.
HDL, rewrite, edit and polish your story and sequel.
That’s how Sci-Fi Grandmasters are thusly honored by their works.
Best of luck in your endeavors.