Drugs to increase hdl

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Actual: decrease LDL (bad) cholesterol and triglyceride levels. increase HDL (good) cholesterol levels. decrease the Total Cholesterol/HDL-Cholesterol Ratio (TC: HDL-C
4.9 rating 2025-04-23
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5 So, although niacin increases HDL-C, it has minimal to no effect on increasing HDL-P. Niacin is an LDL-lowering drug, specifically lowering LDL particle

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There are several basic mechanisms by which a drug can raise HDL cholesterol: an increase in the uptake of cholesterol from tissues by HDLs; an increase in the transfer of cholesterol from other lipoproteins to HDLs; a reduction of the rate of transfer of cholesteryl esters from HDLs to the liver; and a reduction of cholesteryl ester transfer

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While higher HDL levels are correlated with lower risk of cardiovascular diseases, no medication used to increase HDL has been proven to improve health. [2] [32] As of 2024, numerous lifestyle changes and drugs to increase HDL levels were under study. [2]

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by RS Rosenson Cited by 42As examples, simvastatin and rosuvastatin appear to raise HDL cholesterol more as the dose is increased, while the increase in HDL cholesterol

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HDL cholesterol can be a bad thing, drug companies remain invested in identifying drugs to increase HDL cholesterol. Merck recently

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The findings raise questions about drugs in development to raise HDL to prevent heart attacks, he said. Raising HDL through increased ApoA-1

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There are several basic mechanisms by which a drug can raise HDL cholesterol: an increase in the uptake of cholesterol from tissues by HDLs; an increase in the transfer of cholesterol from other lipoproteins to HDLs; a reduction of the rate of transfer of cholesteryl esters from HDLs to the liver; and a reduction of cholesteryl ester transfer

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However, low levels of HDL cholesterol have not been established as causative of this increase in risk. (See 'Low HDL cholesterol as an ASCVD risk factor' below and 'Effect of increasing HDL cholesterol on clinical outcome' below.) This topic will address clinical aspects of abnormal HDL (the particle) and HDL cholesterol.

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Rosuvastatin is an oral drug for lowering blood cholesterol levels. Rosuvastatin is used for the reduction of blood total cholesterol, HDL cholesterol, and triglyceride levels, and to increase HDL cholesterol levels.

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