Pegfilgrastim vs filgrastim

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Actual: Due to a longer half-life and slower elimination rate than filgrastim, pegfilgrastim requires less frequent dosing than filgrastim; however, pegfilgrastim has
4.8 rating 2025-04-24
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However, as the authors highlight, there are also claims for superiority of pegfilgrastim over filgrastim, which has led to considerable debate over the equivalence of filgrastim and pegfilgrastim. Current clinical guidelines in both Europe and the US assume that filgrastim and pegfilgrastim are clinically equivalent [3, 4].

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filgrastim (Granix) and sargramostim (Leukine). Filgrastim and pegfilgrastim products are recombinant granulocyte colony- stimulating

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Compare Filgrastim vs Pegfilgrastim head-to-head with other drugs for uses, ratings, cost, side effects and interactions.

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Prophylaxis with pegfilgrastim was significantly associated with lower FN-related chemotherapy disruption rates (8.3 vs 17.3% in the pegfilgrastim and filgrastim groups, respectively) and fewer FN-related days in hospital (0 vs 15 days, respectively).

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Other treatment-related adverse events including arthralgia (1.7 vs 6%), back pain (6.9 vs 3%) and headache (1.7 vs 6%) were reported for pegfilgrastim vs filgrastim.

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Use of pegfilgrastim vs short-acting G-CSF. Clinical trial data suggest a similar efficacy and safety profile with pegfilgrastim and 11 days filgrastim. 1 If 11 days filgrastim is not utilized, pegfilgrastim should be given in preference to a reduced duration of daily filgrastim (consensus reached (91%); evidence level I).

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Releuko (filgrastim-ayow) Zarxio (filgrastim-sndz) Biosimilars to Neulasta include: Fulphila (pegfilgrastim-jmdb) Fylnetra (pegfilgrastim-pbbk) Nyvepria (pegfilgrastim-apgf) Stimufend (pegfilgrastim-fpgk) Udenyca (pegfilgrastim-cbvq) Ziextenzo (pegfilgrastim-bmez) Though not a biosimilar, Neulasta also has another product called Neulasta On

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Pegfilgrastim, formed by the addition of a polyethylene glycol molecule to filgrastim, has comparable efficacy to filgrastim when administered only once per chemotherapy cycle. High-level evidence indicates that both filgrastim and pegfilgrastim improve the likelihood of completing dose-dense and dose-intense chemotherapy.

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Filgrastim Firmagon Floxuridine Fludarabine Fludara Pegfilgrastim Pegfilgrastim On-Pro Peginterferon Alfa-2b Pemazyre

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