Vancomycin renal dose

Renal function drives vancomycin pharmacokinetics. Because either age or weight is the most relevant covariate of renal maturation, these covariates should be considered first in neonatal vancomycin dosing guidelines and further adjusted by renal dysfunction indicators (e.g, ECMO and ibuprofen/indomethacin).

Renal dosing adjustment and TDM schedule for Vancomycin and Aminoglycoside used in renal CrCl 10 (not on dialysis) : 5mg /kg/ dose OD.

The most accurate and practical method to monitor vancomycin effectiveness is to measure the trough vancomycin concentration prior to the fourth dose . Because vancomycin is cleared by renal excretion, it can be dosed following each dialysis session to maintain therapeutic plasma concentrations .

The frequency of vancomycin dosing depends on patient renal function, a direct correlate of vancomycin clearance. Guidance on the frequency of vancomycin dosing in patients with renal impairment (creatinine clearance [CrCL] 60 mL/minute) is addressed in Therapeutic Guidelines (eTG complete) Antibiotic: Principles of Vancomycin Use.

Adult Vancomycin Initial Dosing - Continuous Renal Replacement Therapy (CVVHD/F) consecutive times, the same vancomycin dose can be

- Weekly vancomycin levels should be obtained for long-term vancomycin use with stable renal function. Desired Levels: Traditional dosing: mcg/ml (to

dose and renal dosage adjustment if applicable Renal dosing adjustment and TDM schedule for Vancomycin and Aminoglycoside used in renal.

with unstable renal function and patients on vancomycin dosing interval more Vancomycin loading dose: mg/kg (maximum 2g) (estimated dry weight).

○ Vancomycin, ciprofloxacin/levofloxacin, and gentamicin are to be 4 Refer to the institutional renal dosing guide (internal only) or tertiary dosing