Enalaprilat injection is used in the management of hypertension when oral therapy is not practical. Enalaprilat is the active metabolite of the oral prodrug enalapril maleate. Enalaprilat is poorly absorbed orally and requires intravenous administration. It inhibits angiotensin I to angiotensin II conversion via competitive inhibition of the angiotensin-converting enzyme (ACE). This activity
benazepril (Lotensin); captopril; enalapril (Vasotec); enalaprilat; fosinopril; lisinopril (Zestril and Prinivil); moexipril; perindopril
Unlabelled: The ACE inhibitor lisinopril is a lysine derivative of enalaprilat, the active metabolite of enalapril. In patients with heart failure
The zinc ligands consist of His383, His387, Glu411, and the C 4 carboxylate oxygen (O 1) of lisinopril or enalaprilat. The O 1 -Zn distance is 2.09 0.14 and 2.08 0.08 for lisinopril and enalaprilat, respectively, which can be compared with the X-ray values of 2.14 and 2.01 .
benazepril (Lotensin) captopril enalapril (Vasotec) enalaprilat fosinopril lisinopril (Zestril and Prinivil) moexipril perindopril
Enalaprilat injection is used in the management of hypertension when oral therapy is not practical. Enalaprilat is the active metabolite of the oral prodrug enalapril maleate. Enalaprilat is poorly absorbed orally and requires intravenous administration. It inhibits angiotensin I to angiotensin II conversion via competitive inhibition of the angiotensin-converting enzyme (ACE). This activity
Enalaprilat is the active metabolite of the oral prodrug enalapril maleate. Enalaprilat is poorly absorbed orally and requires intravenous administration. It inhibits angiotensin I to angiotensin II conversion via competitive inhibition of the angiotensin-converting enzyme (ACE).
Lisinopril. Lisinopril is a lysine derivative of enalaprilat. It does not require hydrolysis to become active. It has a higher affinity for ACE than either
benazepril (Lotensin) captopril enalapril (Vasotec) enalaprilat fosinopril lisinopril (Zestril and Prinivil) moexipril perindopril
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