Bivalirudin half life

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Actual: Heparin does not have a reliable relationship between anticoagulant half-life and concentration half Bivalirudin binds to thrombin in a reversible
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Excretion: Bivalirudin is cleared from plasma by a combination of renal mechanisms and proteolytic cleavage, with a half-life in patients with

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Bivalirudin has a half-life of 25 minutes after intravenous injection and is partially cleared renally; there is no antidote.

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Prolonged half-life in patients with renal impairment. Avoid stasis If bivalirudin is not available, argatroban may also be considered.

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bivalirudin has a short half-life. To date, bivalirudin is licensed for use only in percutaneous coronary interventions (PCI),8 and only a few published

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with this result, bivalirudin reduced systemic thrombin levels by 50% during PCI. Termination of the bivalirudin infusion resulted in rapid clearance of the drug with a half-life of 29.3 minutes. Conclusions Bivalirudin effectively suppresses thrombin-dependent platelet activation via inhibition of PAR1 cleavage

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half-life of 25 minutes and only 20% is excreted through the kidneys (12) d) Bivalirudin has a half-life of approximately 2 hours. 3. Compared to

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Bivalirudin is a synthetic direct thrombin inhibitor that is related to hirudin. The half-life of bi- valirudin is only 25 minutes, and it is predominantly.

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Bivalirudin (Angiomax; The Medicines Company, Parsippany, NJ), a direct The estimated average half-life of bivalirudin in the pediatric population

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Bivalirudin is cleared from plasma by a combination of renal mechanisms and proteolytic cleavage, with a half-life in patients with normal renal function of 25 min. The disposition of bivalirudin was studied in PTCA patients with mild, moderate, and severe renal impairment.

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