NSAIDs block the activity of the cyclooxygenase enzymes, COX-1 and COX-2. Ibuprofen powerful inhibitor. COX-1 and COX-2 oxygenate (add
COX-2 Inhibitors are a type of nonsteroidal anti-inflammatory drug COX-1 and COX-2. Most NSAID medications target both COX-1 and COX-2, but this can lead to stomach and intestinal problems for
COX-1 protects the stomach from ulcers; COX-2 is a protein that, among other things, causes joint inflammation; COX-2 inhibitors are NSAIDs designed to focus on the blocking ( inhibiting ) the COX-2 enzyme. These drugs are called selective inhibitors because they only block the COX-2 protein and not COX-1.
COX-2-specific NSAIDs work by preferentially inhibiting COX-2. Aspirin irreversibly inhibits both COX-1 and COX-2 but inhibits COX-1 more than COX-2. COX inhibitors divide into non-selective nonsteroidal anti-inflammatory drugs (NSAIDs), COX-2 selective nonsteroidal anti-inflammatory drugs (c2s NSAIDs), and aspirin.
Selective COX-2 inhibitors are NSAIDs that block more COX-2 than COX-1. Celecoxib (Celebrex) is currently the only selective COX-2 inhibitor available by
COX-2 inhibitors. Drugs that block either COX-1 or COX-2 can also interfere with the production of prostaglandins that play an important
COX-2 Selective Inhibitors ; S2024, Lornoxicam, Lornoxicam (Chlortenoxicam) is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat
Selective COX-1 inhibitors: indomethacin, piroxicam, sulindac. 3. Selective COX-2 inhibitors: inhibit COX-2 in clinical therapeutic doses, also inhibit COX-1 in higher doses (meloxicam, diclofenac, nimesulid, etodolac) 4. Specific COX-1 inhibitors: inhibit COX-1 without inhibiting COX-2 (no available drug except low doses of aspirin) 5.
NSAIDs block the activity of the cyclooxygenase enzymes, COX-1 and COX-2. Ibuprofen powerful inhibitor. COX-1 and COX-2 oxygenate (add
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Hugs,
Cyndy Cox