Therapeutics. Brands. Cymbalta. Generic Not recommended for use in patients with end-stage renal disease (requiring dialysis) or severe renal impairment
worsening kidney function or increased bleeding. Renal Dosing Guidelines GFR Duloxetine (Cymbalta). Mechanism of Action. It inhibits neuronal
renal disease (ESRD). After a single 60-mg dose of duloxetine, Cmax and AUC Cymbalta (duloxetine hydrochloride) Delayed-release Capsules are
Renal Function: While Cymbalta is primarily metabolized in the liver, a small portion of the drug is excreted unchanged in the urine. Impaired renal function
Limited data are available on the effects of CYMBALTA in patients with end-stage renal disease (ESRD). After a single. 60 mg dose of CYMBALTA, Cmax and AUC
CYMBALTA is not recommended for patients with end-stage renal disease or severe renal impairment (see CONTRAINDICATIONS; WARNINGS AND
worsening kidney function or increased bleeding. Renal Dosing Guidelines Duloxetine (Cymbalta). Mechanism of Action. It inhibits neuronal serotonin
Duloxetine (Cymbalta). Indications. Mechanism of Action. Pharmacokinetics. Adverse Effects. Dosing Guidelines. (Normal Renal. Function). Renal Dosing.
Severe Renal Impairment. CYMBALTA is contraindicated in patients with severe renal impairment (i.e. creatinine clearance. 30 mL/min) or end
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