Artemisinin drugs

Artemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and

First-generation drugs derived from artemisinin. We now know that the unusual structural feature of artemisinin, the 1,2,4-trioxane ring, is the basis for the unique antimalarial action of the drug. It is the endoperoxide linkage in the ring which 'triggers' artemisinin to 'explode' - but only in the vicinity of the Plasmodium parasite. The

How is malaria treated? Artemisinin drugs (artemether and artesunate). The best treatment for Plasmodium falciparum malaria, if available, is artemisinin

by TD Nguyen 2024 Cited by 31Increasing levels of artemisinin and partner drug resistance threaten malaria control and elimination globally. Triple artemisinin-based

ACTs combine an artemisinin derivative (artemisinin derivatives include artesunate, artemether and dihydroartemisinin) with a partner drug. The role of the artemisinin compound is to reduce the number of parasites during the first 3 days of treatment (reduction of parasite biomass), while the role of the partner drug is to eliminate the

Artemisinin is a key ingredient used in antimalarial drugs and Artemisinin-based Combination Therapies (ACTs) are the first-line treatment recommended by

Orally administered artemisinin drug combinations, such as the combination artemisinin-lumefantrine (Coartem), are recommended by WHO as the

That drug is artemisinin, available either by itself as a monotherapy, or with other drugs as a more costly artemisinin combination therapy

Artemisinin drugs (artemether and artesunate). The best treatment for Plasmodium falciparum malaria, if available, is artemisinin combination therapy.