Receptors and drugs

7.2 Drug receptors. Receptor is a macromolecule in the membrane or inside the cell that specifically (chemically) bind a ligand (drug). The binding of a drug to receptor depends on types of chemical bounds that can be established between drug and receptor.

Receptor-mediated drug effects involve two distinct processes: binding, which is the formation of the drug-receptor complex, and receptor activation, which moderates the effect. The term affinity describes the tendency of a drug to bind to a receptor; efficacy (sometimes called intrinsic activity) describes the ability of the drug-receptor

Cholinergic drug acetylcholine receptor agonists muscarine (muscarinic receptors); pilocarpine (M3 receptors); nicotine (nicotinic receptors)

When drugs bind to a receptor, they may modify the receptor in many ways to bring about a biological effect. Agonist: An agonist is a drug that binds to the receptor and enhances the endogenous signaling of the receptor.

Types of Physiologic and Drug-Receptor Proteins). Activated receptors Molecules (eg, drugs, hormones, neurotransmitters) that bind to a receptor are called

Types of Physiologic and Drug-Receptor Proteins). Activated receptors Molecules (eg, drugs, hormones, neurotransmitters) that bind to a receptor are called

Receptor-mediated drug effects involve two distinct processes: binding, which is the formation of the drug-receptor complex, and receptor activation, which moderates the effect. The term affinity describes the tendency of a drug to bind to a receptor; efficacy (sometimes called intrinsic activity) describes the ability of the drug-receptor

An example of receptors. This is the Mu Opioid receptor. Drug antagonists are designed to bind to receptors and specifically block or weaken drug effects.

PHYSIOLOGICAL RECEPTORS. Many drug receptors are proteins that normally serve as receptors for endogenous regulatory ligands. These drug targets are termed